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Systemic administration of therapeutics also results in off-target effects, as only a small fraction of the administered dose crosses the BBB, with the remainder accumulating and affecting peripheral tissues 71,72

patients are required to meet clinical criteria and often undergo lengthy testing to exclude other conditions, a process that is often prolonged, costly, and burdensome for patients

Lecour et al., 2022

The linear increase in absorbance at 412 nm over time was monitored using a microplate reader (SpectraMax M3 Molecular Devices, United States)

Intervertebral disc degeneration: evidence for two distinct phenotypes

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